An orally bioavailable pyrrolinone inhibitor of HIV-1 protease: computational analysis and X-ray crystal structure of the enzyme complex

J Med Chem. 1997 Aug 1;40(16):2440-4. doi: 10.1021/jm970195u.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Administration, Oral
  • Antiviral Agents / administration & dosage
  • Antiviral Agents / chemistry*
  • Antiviral Agents / pharmacokinetics
  • Biological Availability
  • Crystallography, X-Ray
  • Dipeptides / administration & dosage
  • Dipeptides / chemistry
  • Dipeptides / pharmacokinetics
  • Drug Design
  • HIV Protease / metabolism*
  • HIV Protease Inhibitors / administration & dosage
  • HIV Protease Inhibitors / chemistry*
  • HIV Protease Inhibitors / pharmacokinetics
  • Hydrogen Bonding
  • Indinavir / chemistry
  • Indoles / administration & dosage
  • Indoles / chemistry
  • Indoles / pharmacokinetics
  • Models, Molecular
  • Molecular Weight
  • Protein Conformation
  • Pyrroles / administration & dosage
  • Pyrroles / chemistry*
  • Pyrroles / pharmacokinetics

Substances

  • Antiviral Agents
  • Dipeptides
  • HIV Protease Inhibitors
  • Indoles
  • Pyrroles
  • L 685434
  • Indinavir
  • HIV Protease